Production and application of chimeric and single-chain antibodies as positive controls in the diagnosis of infectious diseases by ELISA. The Monoclonal Antibody 3C12C, Targeting CD83 Is a T Cell Sparing, Potential New Immunosuppressive Agent. A method for rapid, ligation-independent reformatting of recombinant monoclonal antibodies. 33rd Annual Scientific Meeting of the Transplantation Society of Australia and new Zealand, Canberra, ACT Australia, 21-23 June 2015. Development of monoclonal antibodies as tools for analysis of PTPRJ function. All rights reserved.
Polyclonal anti-CD83 antibody depletes activated DC and prevents human peripheral blood mononuclear cell (PBMC) induced xenogeneic graft versus host disease (GVHD) in immunosuppressed SCID mice (J Exp Med 2009;206;387). Flower, R., Ekman, S., Mahler, S., Jones, M., Malde, A. K. and Bui, X. Almost all naturally occurring folates are tetrahydro-folates, which are susceptible to oxidation in air, with loss of vitamin activity. Tetrahydrofolate (H4F) and 10-formyltetrahydrofolate are very labile, 5-methyltetrahydro-folate (5... To develop antibodies for diagnostic and therapeutic applications. Host and donor dendritic cells (DC) stimulate alloreactive donor T lymphocytes, and initiate GVHD. Chemical Communications, 52 (33), 5730-5733. doi: 10.1039/C6CC01916A. Jobs. Nanocell targeting using engineered bispecific antibodies.. mAbs, 7 (1), 53-65. doi: 10.4161/19420862.2014.985952, Monoclonal antibody-targeted polymeric nanoparticles for cancer therapy - future prospects, Goodall, Stephen, Jones, Martina L. and Mahler, Stephen (2014). Human Cd83 Expression On Immune Cells Validates Anti-Cd83 Prophylaxis to Prevent Graft Versus Host Disease in Allogeneic Haematopoietic Cell Transplantation.. We describe a set of expression vectors, termed mAbXpress, that enable rapid and sequence-independent insertion of antibody variable... 3554 16/2016).
A method for rapid, ligation-independent reformatting of recombinant monoclonal antibodies, Jones, Martina L., Seldon, Therese, Smede, Matthew, Linville, Ashleigh, Chin, David Y., Barnard, Ross, Mahler, Stephen M., Munster, David, Hart, Derek, Gray, Peter P. and Munro, Trent P. (2010). Chimerization of multiple antibody classes using splice overlap extension PCR. Milk folate-binding protein; ligand-binding properties and polymerization properties. Healthcare Mater. Antibody engineering 3rd ed. The Human Monoclonal Antibody 3C12C, Targeting Activated Dendritic Cells Is a Potential New Immunosuppressive Agent. One possible explanation for the vulnerability of current antibodies used in RDTs is their p... BACKGROUND: Human embryonic kidney-293 (HEK-293) cells are commonly used as a transient expression host but their application in stable therapeutic protein production is limited. doi: 10.1371/journal.pone.0180669, Computational identification of antibody epitopes on the dengue virus NS1 protein, Jones, Martina L., Legge, Fiona S., Lebani, Kebaneilwe, Mahler, Stephen M., Young, Paul R., Watterson, Daniel, Treutlein, Herbert R. and Zeng, Jun (2017). Innovation in diagnosis and treatment of brain metastases using multifunctional nanomedicines. London, United Kingdom: Nature Publishing Group.
The degradation rates of the very labile tetrahydrofolate (H(4)folate) and moderately labile... Folic acid is the parent of a number of derivatives that are vitamins, essential for DNA and amino acid synthesis. Journal of Chemical Technology and Biotechnology, 90 (7), 1169-1176. doi: 10.1002/jctb.4555, Development of a protein nanoparticle platform for targeting EGFR expressing cancer cells, Buecheler, Jakob W., Howard, Christopher B., de Bakker, Christopher J., Goodall, Stephen, Jones, Martina L, Win, Thinzar, Peng, Tao, Tan, Cher Heng, Chopra, Akhil, Mahler, Stephen M and Lim, Sierin (2014).
Bi-specific antibodies (bsAbs) - which exhibit binding capability for two separate targets - offer an inherent advantage over conventional antibody reagents by significan... Introduction: CD83 is an important marker of activated dendritic cells (DC) but it is also expressed on other immune cells.
Commercial kits are available, which facilitate the production and purification of Fab fragments; however, the manufacturer fails to report that this method is inefficient... Recombinant monoclonal antibodies currently dominate the protein biologics marketplace.
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. We aimed to investigate the safety, tolerability, pharmacokinetics, and immunogenicity of m102.4 in healthy adults. Hart, Derek N. J., Ju, Xinsheng, Elgundi, Zehra, Verma, Nirupama, Silveira, Pablo, Fromm, Phillip, Alingcastre, Renz, Hsu, Blake, Munster, David J., Seldon, Therese, Sheng, Yonghua, Jones, Martina, Munro, Trent, Mahler, Stephen, Barnard, Ross, Vu, Al, Lo, Tsun Ho, Shahin, Kifah, Larsen, Stephen Robert, Bradstock, Kenneth and Clark, Georgina (2015).
Seldon, Therese A., Hughes, Karen E., Munster, David J., Chin, David Y. and Jones, Martina L. (2011). Milk folate-binding protein; ligand-binding properties and polymerization properties. Our aim was to engineer BsAbs to target a novel nanocell (EnGeneIC Delivery Vehicle or EDV(TM)nanocell) to the epidermal growth factor receptor (EGFR). 57th Annual Meeting of the American Society of Hematology, Orlando, FL, United States, 5-8 Dec 2015. Operations Manager - National Biologics Facility. Retooling phage display with electrohydrodynamic nanomixing and nanopore sequencing. Availability of folate bound to folate-binding protein: Environmental effects.
Scientific Reports, 6 (1) 26240, 26240. doi: 10.1038/srep26240, Biosensing made easy with PEG-targeted bi-specific antibodies, Raftery, Lyndon J., Grewal, Yadveer S., Howard, Christopher B., Jones, Martina L., Shiddiky, Muhammad J. Efforts to develop and deploy effective vaccines against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continue at pace with more than 30 candidate vaccines now in clinical evaluation. Labile folates appear to be stabilized by binding to folate-binding protein (FBP); this paper reports measurements of that stabilization.
: Abstract# D2342, Clonal selection of high producing, stably transfected HEK293 cell lines utilizing modified, high-throughput FACS screening, Improved Protein-A separation of VH3 Fab from Fc after Papain Digestion of Antibodies, Availability of folate bound to folate-binding protein: Environmental effects, A method for rapid, ligation-independent reformatting of recombinant monoclonal antibodies, Developing a Therapeutic Anti - Dendritic Cell Antibody to Prevent Graft Versus Host Disease, Use of Chimeric Antibodies as Positive Controls in an Enzyme-Linked Immunosorbent Assay for Diagnosis of Scrub Typhus (Infection by Orientia tsutsugamushi), Chimerization of multiple antibody classes using splice overlap extension PCR, Dietary Interactions Influence the Effects of Bovine Folate-Binding Protein on the Bioavailability of Tetrahydrofolates in Rats1, Tetrahydrofolates Are Greatly Stabilized by Binding to Bovine Milk Folate-Binding Protein, Tetrahydrofolates are great stabilized by binding to bovine milk folate-binding protein, Stability of labile folate is enhanced by binding milk folate-binding protein. 51st Annual Meeting of the American Society of Hematology, New Orleans LA, 5-8 December 2009. For further information regarding the NBF services, pricing, equipment or capabilities, please don’t hesitate to contact us: Phone: +61 7 3346 3178 E-mail: firstname.lastname@example.org, Australian Institute for Bioengineering and NanotechnologyBldg 75, Corner College and Cooper RoadsThe University of QueenslandSt Lucia, Brisbane Qld 4072, Phone: +61 3 9518 5917E-mail: email@example.com, Biomedical Manufacturing, CSIRO Clayton, Victoria VIC 3168. The Monoclonal Antibody 3C12C, Targeting CD83 Is a T Cell Sparing, Potential New Immunosuppressive Agent, Hart, D, Verma, N., Seldon, T, Sheng, Y., Pryor, R., Palkova, A., Findova, M., Jones, M., Munro, T., Mahler, S., Braet, K., Barnard, R., Marks, J., Coley, A., Fan, F., Zhou, Y., Vu, P, Lo, K., Shahin, K., Elgundi, Z., Silveira, P., Fromm, P., Clark, G., Larsen, S., Bradstock, K. and Munster, D. (2014). Wavelength-dependent fluorescent immunosensors via incorporation of polarity indicators near the binding interface of antibody fragments. Analytical Chemistry, 91 (12), 7631-7638. doi: 10.1021/acs.analchem.9b00445, Use of bacteriophage for discovery of therapeutically relevant antibodies against infectious diseases, Jones, Martina L. (2019).
(Honours) (Biotechnology). University students and faculty, institute members, and independent researchers, Technology or product developers, R&D specialists, and government or NGO employees in scientific roles, Health care professionals, including clinical researchers, Journalists, citizen scientists, or anyone interested in reading and discovering research. Isolation of serotype-specific antibodies against dengue virus non-structural protein 1 using phage display and application in a multiplexed serotyping assay. Malden, MA United States: Wiley-Blackwell Publishing, Inc.. doi: 10.1111/ajt.12888, Developing a Therapeutic Anti - Dendritic Cell Antibody to Prevent Graft Versus Host Disease.
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